MS-BASED APPROACHES ENABLE THE STRUCTURAL CHARACTERIZATION OF TRANSCRIPTION FACTOR/DNA RESPONSE ELEMENT COMPLEX

MS-Based Approaches Enable the Structural Characterization of Transcription Factor/DNA Response Element Complex

The limited information available on the structure of complexes involving transcription factors and cognate DNA response elements represents a major obstacle in the quest to understand their mechanism of action at the molecular level.We implemented a concerted structural proteomics approach, which combined hydrogen-deuterium exchange (HDX), quantit

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PHILOS plate fixation with polymethyl methacrylate cement augmentation of an osteoporotic proximal humerus fracture

PHILOS plate fixation in osteoporotic proximal humerus fracture of old age is well-known for high complication rate, peperomia double duty especially metal failure, providing various augmentation techniques, such as calcium phosphate cement, allogenous or autologous bone graft.We report a case of polymethyl methacrylate augmentation to provide appr

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